live blood microscopy

What is LBM? - What does LBM provide? - Can LBM be used to monitor therapy

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Standard hospital laboratory blood sampling, for microscopy purposes, involves smearing the blood onto a slide and then staining it. Although this technique has many uses, it kills the blood cells and modifies their appearance under the microscope.
Live Blood Microscopy examines the blood in its living state and records moving images of the blood in the form of digital computer files for later study and evaluation.

Live Blood Microscopy (LBM) is not available on the National Health Service at the present time.

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A picture of living healthy blood, magnified 5000 times

Live blood

A Leica microscope suitable for Live Blood Microscopy

Leica microscope

LBM is a technique in which the blood is viewed immediately in its living state and the picture recorded onto a sophisticated video editing programme, with commentary, for further study and evaluation.

Using an automatic spring-loaded needle, a tiny drop of blood is taken from a fingertip, an almost painless procedure. The sample is immediately magnified up to 5000 times under a microscope. A camera displays the result on a high-resolution monitor. Both doctor and patient then study the appearance of the living blood.

Under strictly controlled conditions, human white cells (leucocytes) continue to live for up to nine hours after leaving the body.  However, by developing an original sampling technique, I am now able to keep leucoctes on a slide alive for over 24 hours.

For research purposes, further recordings are taken, after some months of therapy, for comparative purposes.

LBM provides an immediate visual picture of the blood. Under LBM, healthy red blood cells shimmer with life.

White cells move through the plasma, performing their functions. There are no bacteria, fungi, parasites or other impurities in the plasma.

Unhealthy blood may show changes in red cell structure.  White cell sluggishness may also be apparent.

Can LBM be used to monitor the clinical effect of therapy?
The answer to this question is unknown at present, but the outlook is bright.
A complementary therapy regime is based on each individual patient’s clinical picture. The effect of such a regime is usually monitored subjectively by asking patients how their bodies feel before and after therapy.This is, at best, an unreliable procedure.

It is possible that LBM will eventually offer patients a visual confirmation of the way they feel. It is possible that it could be used to monitor the effect of therapeutic regimes objectively and to relate the blood changes to subjective improvements felt by patients.
These experiences could encourage and motivate patients. They could provide huge relief to those ME/CFS/FM sufferers who have met with varying degrees of disbelief in the past. They could increase therapeutic compliance. They could also encourage the physician by providing an objective evaluation of the therapy. They could enhance the relationship between doctors and their patients

At the present time, no diagnostic value has been firmly established for Live Blood Microscopy, but it may eventually prove to be a useful clinical tool.

This possibility is currently being researched by Overton Studios Trust. In this connection, a parameter known as the 'Neutrophil Vitality Index' is showing promise. The 'Neutrophil Vitality Index' seems to be significantly reduced in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome sufferers. For more information about the 'Neutrophil Vitality Index', please Contact  Dr Midgley and ask for his paper, NVI.doc, to be e-mailed back to you.

A 25-minute video from Overton Studios Trust.  A video for patients, practitioners and researchers.  Please Contact Dr Midgley for details.

Live Blood Microscopy is frowned on by orthodox medical science and there are good reasons for this. Nevertheless, I believe that Live Blood Microscopy may have some advantages over the standard laboratory procedure.

As a result, I created this video. It represents the current state of my ongoing research into the possible value of Live Blood Microscopy in clinical practice and particularly its relationship to patients suffering from Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS) or Fibromyalgia (FM).
One exciting parameter, which I call the Neutrophil Vitality Index, enables me to measure, fairly accurately, the vitality of living neutrophils in the circulating blood. It is early days yet, but the Neutrophil Vitality Index seems to be significantly reduced in ME, CFS and FM sufferers, as compared with healthy controls. I am investigating this.
It will be of interest to ME/CFS/FM sufferers, to Complementary Health Professionals and to researchers.
Dr Michael Midgley, MB, ChB, MRCGP, MBKS.

Live Blood Microscopy (LBM) has been around since microscopes emerged from their adolescence and began to resemble something that a modern pathologist might recognise.
Metchnikoff used LBM in the late 19th century to describe phagocytosis.

But, in order to get hard and useful information for the patient in the clinic, pathologists soon discovered that the cells must be fixed and stained first. This imposes artificial restraints on what can be learned and failure to use LBM in conventional hospital laboratories is not due to stupidity or to want of trying. Conventional pathologists have been down this road many times over the years and it takes an intrepid amateur to claim success where they have repeatedly failed.
Nevertheless, new ideas and new situations do occur in Medicine. A case in point is Myalgic Encephalomyelitis and its associated conditions, Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM). Still controversial, there is no agreement over their definition, their features, their treatment and even, in some quarters, their existence. Many physiological abnormalities have been reported but there is still no reliable test for these conditions and they remain an amorphous clinical entity (though not to the sufferer!).

Here Mike Midgley comes into his own. A sufferer (in remission) himself, and now armed with optical and electronic hardware undreamt-of by his predecessors, he picks up where Metchnikoff left off. This video presents his findings so far. In some ways LBM falls far short of the claims made by its purveyors, notably repeatability. But, with close attention to sampling technique, Dr Midgley appears to have ironed out most of the artefactual difficulties. His preliminary findings on neutrophil activation and vitality are extremely interesting and, if the same pattern emerges from larger-scale studies, this will be a genuine breakthrough.

The reputation of LBM has suffered from over-enthusiastic promotion. This is a great pity because the technique is far from dead and may yet have much to teach.

If you are interested in LBM, either as a practitioner, a researcher or as a patient, this video is a must.

Director, Salford Allergy Clinic

This 25-minute film is available worldwide as a  VHS Cassette or a DVD, in either PAL (UK etc) or NTSC (USA etc) formats. Contact us if you are unsure which you need.

By buying direct from the publisher, you save 21% on the Recommended Retail Price!  

Price to UK Customers = 20.00  Price to Overseas Customers = 22.00.

These prices may seem expensive.  But remember that they defray only a tiny fraction of the tens of thousands of pounds of capital outlay involved in their production.  We rely on donations and sponsorship to make up the difference.

If you have any difficulty, simply Contact Overton Studios Trust for help.

There are two methods for ordering this film.  Please scroll down to find the method that suits you best.  Your copy of 'Live Blood Microscopy' will be posted to you on the day we receive your order, unless the office is closed for our annual 2-week holiday.

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